Antiepileptic medication are related to incident Parkinson illness, in line with a examine revealed on-line Dec. 27 in JAMA Neurology.
Daniel Belete, M.B.Ch.B., from Queen Mary College of London, and colleagues have investigated the affiliation between antiepileptic medication and incident Parkinson illness utilizing information from 1,433 people with a Parkinson illness analysis and eight,598 matched controls. Routinely collected prescription information derived from main care had been used to outline publicity to antiepileptic medication (carbamazepine, lamotrigine, levetiracetam, and sodium valproate).
The researchers noticed an affiliation between antiepileptic drug prescriptions and incident Parkinson illness (odds ratio, 1.80) in a dose-response trend, with a pattern for a better variety of prescription points and a number of antiepileptic medication being related to a better danger for Parkinson illness.
“To one of the best of our information, that is the primary observational examine to analyze a spread of antiepileptic medication and their affiliation with incident Parkinson illness. As such, it units the scene and highlights the necessity for additional work to corroborate our findings in different giant information units as a result of these findings might have necessary implications for scientific decision-making,” the authors write. “The underlying causes for an affiliation between antiepileptic medication and Parkinson illness must be additional explored.”
Daniel Belete et al, Affiliation Between Antiepileptic Medicine and Incident Parkinson Illness within the UK Biobank, JAMA Neurology (2022). DOI: 10.1001/jamaneurol.2022.4699
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Antiepileptic medication tied to incident Parkinson illness (2023, January 4)
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